Poisoning by Organophosphorus Compounds

• Q1.Treatment of Endrin poisoning is with

  • AAtropine
  • BOximes
  • CSupportive measures
  • DAll of the above
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• Q2.A farmer with pinpoint pupils, increased secretions and urination. What is the most likely diagnosis?

  • AOrganophosphate poisoning
  • BOpioid poisoning
  • CAlcohol poisoning
  • DAtropine poisoning
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• Q3.Mechanism of action of atropine in treatment of organophophate poisoning is?

  • AIt inhibits secretion of acetylcholine
  • BIt is reactivator of acetylcholine esterase enzyme
  • CIt has antimuscarinic activity
  • DIt is agonist of acetylcholine receptors
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• Q4.A 40 YR OLD MAN , WORKING IN FARM PRESENTED WITH HEADACHE MALAISE SENSE OF TIGHTNESS DIMNESS OF VISION . ON EXAMINATION PUPILS WERE SHOWN AS BELOW ? WHAT IS THE DIAGNOSIS ?

  • ALEAD POISONING
  • BORGANO PHOSPHOROUS
  • CNICKEL POISONING
  • DCOCAINE
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• Q5.All of the following statements about pralidoxime in organophosphate poisoning are true except:-

  • AIt is given intravenously
  • BIt should be started after 24 hours of poisoning
  • CIt does not cross blood brain barrier
  • DReactivates the AChE enzyme
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• Q6.A lady was brought from village, unconscious, about 12 hours after ingesting some kind of unknown poison. Her heart rate was 103/min, blood pressure in 90/50 mm Hg and respiratory rate is 19/min. Her breath smelled like kerosene. All of the following should be done in her management, except:

  • AGastric lavage should be done
  • BAtropine should be administered till signs of recovery
  • CVasopressors should be administered intravenously
  • DImmediate airway management
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• Q7.A patient with Suspected Poisoning with meiosis, Increased Bronchial Secretions & salivation from Angle of mouth. What type of Antidote is to be Given.

  • AAtropine
  • BEDTA
  • CNeostigmine
  • DBelladonna
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• Q8.Atropine is not an antidote in:

  • ATik 20
  • BEndrin
  • CBaygon
  • DParathion
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• Q9.A patient comes with pinpoint pupil, salivation, tremors, and red tears. Cholinesterase activity was 30% normal. Probable diagnosis is:

  • AOpium
  • BOrganophosphate poisoning
  • CDhatura
  • DOrganochloride pesticide poisoning
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• Q10.A patient presented to emergency with overdose some drug. There were increased salivation and increased bronchial secretions. On examination, blood pressure was 88/60 mmHg. RBC esterase level is 50. What should be the treatment of this person?

  • ANeostigmine
  • BAtropine
  • CFlumazenil
  • DPhysostigmine
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Answer key

Q1: C. Supportive measures; Q2: A. Organophosphate poisoning; Q3: C. It has antimuscarinic activity; Q4: B. ORGANO PHOSPHOROUS; Q5: B. It should be started after 24 hours of poisoning; Q6: A. Gastric lavage should be done; Q7: A. Atropine; Q8: B. Endrin; Q9: B. Organophosphate poisoning; Q10: B. Atropine.

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