Non-Depolarising Neuromuscular Blockers

• Q1.Probable indicators of reversal of neuromuscular blockade are all Except

  • ALift head for 5 seconds
  • BSustain hand grip for 5 seconds
  • CLeg lift for 10 seconds
  • DAbility to perform sustained tongue depressor test
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• Q2.Which drug can be eliminated by nonenzymatic degradation -

  • AAtracurium
  • BPancuronium
  • CMivacurium
  • DDoxacurium
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• Q3.A person was given a muscle relaxant that competively blocks nicotinic receptors which of the following drug is used for reversal of muscle relaxation after surgery ?

  • APHYSOSTIGMINE
  • BNEOSTIGMINE
  • CCARBACHOL
  • DSUCCINYL CHOLINE
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• Q4.Laudanosine is a toxic metabolite of ?

  • AAtracurium
  • BPancuronium
  • CMivacurium
  • DVecuronium
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• Q5.Reason for preferring cis-Atracurium over Atracurium is

  • ADoes not undergo Hoffman elimination
  • BShort and fast action
  • CLesser provocation of histamine release
  • DEqual potency like Atracurium
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• Q6.Mechanism of action of d-tubocurarine is:-

  • ACompetitive, nondepolarizing block at the Nm cholinergic receptor
  • BNon-competitive, nondepolarizing block at the Nm cholinergic receptor
  • CCompetitive, depolarizing block at the Nm cholinergic receptor
  • DNoncompetitive, depolarizing block at the Nm cholinergic receptor
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• Q7.A patient was administered a competitive neuromuscular blockade which acts on nicotinic receptor At the end of surgery which of the following drugs can be administered to reverse the effects of that drug

  • ASuccinyl choline
  • BNeostigmine
  • CPhysostigmine
  • Dcarbochol
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• Q8.Which of the following is eliminated by Hoffmann elimination?

  • AAlthesin
  • BD'Tubocurarine
  • CPancuronium
  • DAtracurium
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• Q9.Which drug can be eliminated by nonenzymatic degradation

  • AAtracurium
  • BPancuronium
  • CMivacurium
  • DDoxacurium
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• Q10.What is mechanism of action of curonium drugs as muscle relaxant?

  • APersistently depolarizing at neuromuscular junction
  • BAct competitively on Ach receptors blocking postsynaptically
  • CRepetitive stimulation of Ach receptors on muscle end plate
  • DInhibiting the calcium channels on presynaptic membrane
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Answer key

Q1: C. Leg lift for 10 seconds; Q2: A. Atracurium; Q3: B. NEOSTIGMINE; Q4: A. Atracurium; Q5: C. Lesser provocation of histamine release; Q6: A. Competitive, nondepolarizing block at the Nm cholinergic receptor; Q7: B. Neostigmine; Q8: D. Atracurium; Q9: A. Atracurium; Q10: B. Act competitively on Ach receptors blocking postsynaptically.

Other topics in Anaesthesia

• History and Ethics of Anaesthesia
• Preoperative Assessment of the Patient
• Intraoperative CNS and CVS Monitoring
• Respiratory Monitoring During Anaesthesia
• Devices for Airway Management
• Intubation
• Anaesthetic Breathing Circuits
• The Anaesthesia Machine and Workstation
• Basic and Paediatric Life Support (BLS and PALS)
• ACLS
• Ventilators and O2 Delivery Devices
• Depolarising Neuromuscular Blockers
• Inhaled Anaesthetics: Basic Properties, N2O and Halothane
• Inhaled Anaesthetics: Fluorinated and Inert Agents with Therapeutic Gases
• Intravenous Anaesthesia: Barbiturates, Benzodiazepines and Propofol
• Intravenous Anaesthesia: Etomidate, Ketamine and Day-care Surgery
• Local Anaesthetics: Pharmacology and Properties
• Local Anaesthetics: Individual Agents
• Regional Anaesthesia: Methods and Approaches
• Regional Anaesthesia: Risks and Contraindications
• Peripheral Nerve Blockade
• Anaesthetic Implications of Coexisting Disease
• Anaesthesia in Paediatrics and Obstetrics
• Pain Management: Postoperative, Chronic and Cancer Pain
• Perioperative Anaesthetic Complications