Disorders of Immunity

• Q1.Meningococcal meningitis is seen with which of the following complement deficiency?

  • AC1q
  • BC2
  • CC4
  • DC5
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• Q2.A child presents with recurrent episodes of sinopulmonary infection by bacteria with polysaccharide rich capsule. Deficiency of which of the following immunoglobulin subclasses should be specifically investigated -

  • AIgA
  • BIgG1
  • CIgG2
  • DIgA + IgG2
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• Q3.Chediak higashi syndrome, defect is -

  • AFusion of lysosome
  • BT-cells
  • CB-cells
  • DComplement
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• Q4.In a 4-year old boy who has history of pyogenic infections by bacteria with polysaccharide-rich capsules, which of the following investigations should be done?

  • AIgA deficiency
  • BIgG 1 deficiency
  • CIgG2 deficiency
  • DIgA and IgG2 deficiency
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• Q5.Meningococcal (Neisseria meningitidis) infection is predisposed by deficiency of -

  • ALate complement
  • BEarly complement
  • CC1 esterase
  • DAll of the above
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• Q6.Chediak-Higashi syndrome

  • ADisorders of specific immunity
  • BDisorders of complement
  • CDisorders of phagocytosis
  • DSecondary immunodeficiencies
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• Q7.A young girl has had repeated infections with Candida albicans and respiratory viruses since the time she was 3 months old. As part of the clinical evaluation of her immune status, her responses to routine immunization procedures should be tested. In this evaluation, the use of which of the following vaccines is contraindicated?

  • ADiphtheria toxoid
  • BBordetella pertussis vaccine
  • CTetanus toxoid
  • DBCG
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• Q8.Neisseria infection are associated with ?

  • ADeficiency of early complements
  • BDeficiency of late complements
  • CThere is no such association
  • DAny deficiency can be associated
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• Q9.A child is suffering from recurrent chronic infections with encapsulated bacteria; Which subclass of IgG does the child has deficiency?

  • AIgG1
  • BIgG2
  • CIgG3
  • DIgG4
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• Q10.Job syndrome is due to

  • ADefect in chemotaxis
  • BDefect in phagocytosis
  • CDefect in synthesis
  • DDefect in leukocyte function
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Answer key

Q1: D. C5; Q2: D. IgA + IgG2; Q3: A. Fusion of lysosome; Q4: D. IgA and IgG2 deficiency; Q5: A. Late complement; Q6: C. Disorders of phagocytosis; Q7: D. BCG; Q8: B. Deficiency of late complements; Q9: B. IgG2; Q10: A. Defect in chemotaxis.

Other topics in Microbiology

• Principles of General Microbiology
• Cells and Organs of the Immune System
• Immune System: Organisation, Function and Response
• Hypersensitivity
• Streptococci and Enterococci
• Staphylococci
• Corynebacterium, Listeria and Actinomyces
• Clostridium and Bacillus
• Non-Sporing Anaerobes
• Mycobacterium Tuberculosis
• Mycobacteria Other Than Tuberculosis
• Escherichia, Proteus and Klebsiella
• Shigella and Salmonella
• Vibrio and Campylobacterales
• Pseudomonas and Burkholderiales
• Haemophilus
• Yersinia, Brucella, Bartonella and Legionella
• Gram-Negative Cocci
• Rickettsia, Chlamydia and Mycoplasma
• Spirochetes
• Virus Structure and General Properties
• DNA Viruses
• Hepatitis
• HIV
• Myxoviruses and Rhabdoviruses
• Arboviruses and Picornaviruses
• Rubella, Coronaviruses, Prions, Rotavirus, Filovirus, Zika Virus and Nipah Virus
• Superficial and Systemic Fungal Infections
• Opportunistic Fungal Infections
• Principles of Parasitology
• Protozoa: Amoebae, Ciliates and Flagellates
• Protozoa: Sporozoa
• Helminths: Cestodes and Trematodes
• Helminths: Nematodes
• Applied Clinical Microbiology