Mendelian and Non-Mendelian Inheritance Disorders
- Previous year questions on Mendelian and Non-Mendelian Inheritance Disorders for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Paediatrics section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 37 live questions in Mendelian and Non-Mendelian Inheritance Disorders.
- 2 of 37 questions carry a verified exam year: 2019.
- Paediatrics is worth about 10 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.False about The mitochondrial disorders
- AMay present at any age and by mode of inheritance
- BInclude Pearson's syndrome
- CFeatures may include retinitis pigmentosa
- DElevated free-floating blood lactate do not support the diagnosis✓ Correct answer
Q2.Laurence moon biedl syndrome is associated with
- APolydactyly
- BMental retardation
- CRetinitis pigmentosa
- DAll of the above✓ Correct answer
Q3.True about Fragile X syndrome is
- AGain of function mutation
- BMales have IQ 20-40✓ Correct answer
- C10% Female carriers are mentally retarded
- DTriple nucleotide CAG Sequence mutation
Q4.4yr old boy presenting with cryptorchidism, short stature & on auscultation, harsh ejection systolic murmur is heard in pulmonary area. What is the hematological abnormality found in this condition?
- ATransient Myeloproliferative disorder
- BJuvenile Myelomonocytic leukemia✓ Correct answer
- CPseudo Pelger Huet anomaly
- DBurkitt lymphoma
Q5.The risk of recurrence of congenital heart disease is
- A0.80%
- B1%
- C2-6%✓ Correct answer
- D10-12%
Q6.Polydactyly, craniosynostosis, Late closure of fontanelles is a feature of:
- AApert's syndrome✓ Correct answer
- BCrouzon's syndrome
- CPierre robin syndrome
- DDown' syndrome
Q7.The chances of having an unaffected baby, when both parents have achondroplasia, are –
- A0%
- B25%✓ Correct answer
- C50%
- D100%
Q8.All of the following syndromes are associated with uniparental disomy except-
- APrader-Willi syndrome
- BRussell-Silver syndrome
- CBloom syndrome✓ Correct answer
- DAngelman syndrome
Q9.Which of the following is not an example of a syndrome caused by uniparental disomy?
- APrader-Willi syndrome
- BAngelman syndrome
- CRussell-Silver syndrome
- DBloom syndrome✓ Correct answer
Q10.A parent is homozygous and a parent heterozygous for an autosomal recessive gene. What will be the outcome –
- A75% children affected
- BNo child affected, but all are carriers
- C50% children affected, rest are carriers✓ Correct answer
- D25% children affected, rest are carriers
Answer key
Q1: D. Elevated free-floating blood lactate do not support the diagnosis; Q2: D. All of the above; Q3: B. Males have IQ 20-40; Q4: B. Juvenile Myelomonocytic leukemia; Q5: C. 2-6%; Q6: A. Apert's syndrome; Q7: B. 25%; Q8: C. Bloom syndrome; Q9: D. Bloom syndrome; Q10: C. 50% children affected, rest are carriers.
Other topics in Paediatrics
- Neonatology Basics and Routine Newborn Care
- Disorders of the Newborn
- Neonatal Conditions Requiring Special Care
- Apgar Scoring and Neonatal Resuscitation
- Milestones of Development
- Patterns of Growth and Development
- Infant Nutrition and Breastfeeding
- Protein-Energy Malnutrition
- Fat-Soluble Vitamin Deficiencies
- Water-Soluble Vitamin and Trace Element Deficiencies
- Disorders of Fluid and Electrolyte Balance
- Chromosomal Abnormalities
- Inborn Errors of Amino Acid Metabolism
- Urea Cycle, Complex Molecule and Carbohydrate Metabolic Disorders
- Poliomyelitis and HIV/AIDS
- Bacterial and Parasitic Infections in Children
- Measles, Mumps, Rubella and Other Viral Illnesses
- Surgical GI Conditions in Children
- Medical GI Conditions in Children
- Paediatric Liver Disorders
- Respiratory Disorders of the Newborn
- Respiratory Disorders in Childhood
- Fetal Circulation
- Acyanotic Congenital Heart Disease
- Cyanotic Congenital Heart Disease
- Nephrology in Children
- Urology in Children
- Disorders of the Paediatric Nervous System
- Thyroid Disorders in Children
- Congenital Adrenal Hyperplasia and Allied Adrenal Disorders
- Pituitary Gland Disorders
- Pubertal Disorders
- Paediatric Haemato-oncology
- Childhood Solid Tumours
- Musculoskeletal Disorders in Children
- Rheumatological Disorders in Children
- Paediatric Haematology: Bleeding and Clotting Disorders
- Paediatric Anaemias