Glycogen Metabolism and Storage Diseases
- Previous year questions on Glycogen Metabolism and Storage Diseases for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Biochemistry section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 19 live questions in Glycogen Metabolism and Storage Diseases.
- 4 of 19 questions carry a verified exam year: 2017, 2018.
- Biochemistry is worth about 16 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.Which is branching enzyme?
- AGlycogen synthetase
- BGlucose-6 phosphatase
- CAmylo-1, 4-1, 6-transglycosylase✓ Correct answer
- DGlycogen Phosphorylase
Q2.Blood glucose levels cannot be augmented by mobilization of muscle glycogen due to lack of:
- AG-6-P dehydrogenase
- BG-6-phosphatase✓ Correct answer
- CAldolase
- DGlucokinase
Q3.fanconi bickel syndrome is due to mutation of ?
- Aglut 1
- Bglut 2✓ Correct answer
- Cglut 4
- Dna+iodine channels
Q4.Both the liver and muscle contain glycogen, yet, unlike liver, muscle is not capable of contributing glucose to the circulation because muscle:
- ADoes not have the enzyme glucose-6-phosphatase✓ Correct answer
- BGlycolytic activity consumes all of the glucose it generates
- CDoes not have the enzyme glucose-1-phosphatase
- DDoes not have the enzyme glycogen phosphorylase
Q5.Acid maltase deficiency occurs in
- APompe's disease✓ Correct answer
- BVon-gerke's disease
- CMc-ardle's disease
- DNeimen pick disease
Q6.Which of the following enzyme is absent in muscle ?
- AGlucose-1-phosphatase
- BGlucose-6-phosphatase✓ Correct answer
- CGlycogen phosphorylase
- DThiophorase
Q7.Increased risk of liver adenoma is found in which of the following diseases?
- ALipid storage disorder
- BMitochondrial disease
- CGlycogen storage disorder✓ Correct answer
- DLysosomal storage disorder
Q8.Which of the following enzyme is common between glycogenesis and glycogenolysis?
- AGlycogen synthase
- BGlycogen phosphorylase
- CGlucan transferase
- DPhosphoglucomutase✓ Correct answer
Q9.Glycogen synthesis and breakdown takes place in the same cell, having enzymes necessary for both the pathways. Why the glucose-6-phosphate, freshly synthesized during glycogenesis in cytoplasm of hepatocytes, is not immediately degraded by the enzyme glucose-6-phosphatase?
- AThe thermodynamics does not favor such a reaction to occur
- BGlucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm✓ Correct answer
- CGlycogenesis and glycogenolysis are tightly regulated such that enzymes of only one of those is present at a time.
- DSteric hindrance due to albumin
Q10.Which vitamin is required for glycogen Phosphorylase?
- APLP✓ Correct answer
- BTPP
- CRiboflavin
- DLipoic acid
Answer key
Q1: C. Amylo-1, 4-1, 6-transglycosylase; Q2: B. G-6-phosphatase; Q3: B. glut 2; Q4: A. Does not have the enzyme glucose-6-phosphatase; Q5: A. Pompe's disease; Q6: B. Glucose-6-phosphatase; Q7: C. Glycogen storage disorder; Q8: D. Phosphoglucomutase; Q9: B. Glucose-6-phosphatase is present in the endoplasmic reticulum and cannot act on glycogen formed in the cytoplasm; Q10: A. PLP.
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- Krebs Cycle
- Amino Acids: Structure and Classification
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- Levels of Protein Structure and Function
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- Lipids: Classification and Chemistry
- Beta-Oxidation and Ketone Body Formation
- Fatty Acid Synthesis and Eicosanoids
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- Enzymes: Mechanism of Action and Clinical Uses
- Enzyme Kinetics, Inhibition and Regulation
- Fat-Soluble Vitamins: A, D, E and K
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- Minerals and Antioxidant Systems
- Nucleotide Metabolism and Its Disorders
- DNA Packaging, Replication and Repair
- Transcription and RNA Processing
- Translation and Post-Translational Modification
- Control of Gene Expression
- Recombinant DNA and Genomic Techniques