HMP Shunt with Fructose and Galactose Metabolism
- Previous year questions on HMP Shunt with Fructose and Galactose Metabolism for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Biochemistry section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 10 live questions in HMP Shunt with Fructose and Galactose Metabolism.
- 3 of 10 questions carry a verified exam year: 2018, 2019.
- Biochemistry is worth about 16 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.The enzyme deficient in Galactosemia is:
- AHexoseaminidase B
- BHexosaminidase A
- CGalactose 1 phosphate uridyltransferase✓ Correct answer
- DGlucocerebrosidase
Q2.Most Common enzyme deficient in galactosemics:
- AGalactose-1-phosphate uridyl transferase/GALT✓ Correct answer
- BGalactosidase
- CUDP galactose epimerase
- DGalactokinase
Q3.Which of the following is not the source of cytosolic NADPH
- AMalic enzyme
- BIsocitrate dehydrogenase
- CATP citrate lyase✓ Correct answer
- D6-phospho gluconate dehydrogenase
Q4.Dehydrogenase in HMP shunt act in oxidative phase to generate which of the following?
- ANADP+
- BNADPH✓ Correct answer
- CFAD+
- DFADH
Q5.The first step in fructose metabolism in the liver is
- AIsomerization of glucose
- BPhosphorylation to fructose 1, 6 bisphosphate by ATP
- CPhosphorylation to fructose 6 phosphate by ATP
- DPhosphorylation to fructose 1 phosphate by ATP✓ Correct answer
Q6.True regarding galactosemia
- AThere is an incidence of 1 in 6000
- BThe enzyme deficiency is glucose phosphorylase
- CThere is an inability to metabolize galactose and lactose✓ Correct answer
- DDiagnosis is by WBC enzyme assay
Q7.NADPH actions in RBC are a/e
- AProduce ATP✓ Correct answer
- BStabilizes the membrane
- CReductive biosynthesis
- DG6PD deficiency causes decreased synthesis of NADPH
Q8.classical type of galactosemia is due to deficiency of ?
- Agalactokinase
- Baldose reductase
- Cgalactose 1-p uridyl transferase✓ Correct answer
- Dgalactose dehydrogenase
Q9.A patient has normal blood glucose level as estimated by glucose-oxidase peroxidase method, shows positive Benedicts test in urine. Which of the following is the most likely cause?
- AFructosemia
- BDenaturation of glucose
- CGalactosemia✓ Correct answer
- DFalse positive
Q10.The metabolic defect in HEREDITARY FRUCTOSE INTOLERANCE is due to deficiency of enzyme:
- AFructokinase
- BAldolase-B✓ Correct answer
- CXylitol dehydrogenase
- DPhosphofructokinase
Answer key
Q1: C. Galactose 1 phosphate uridyltransferase; Q2: A. Galactose-1-phosphate uridyl transferase/GALT; Q3: C. ATP citrate lyase; Q4: B. NADPH; Q5: D. Phosphorylation to fructose 1 phosphate by ATP; Q6: C. There is an inability to metabolize galactose and lactose; Q7: A. Produce ATP; Q8: C. galactose 1-p uridyl transferase; Q9: C. Galactosemia; Q10: B. Aldolase-B.
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