Glycolysis, Gluconeogenesis and Their Regulation
- Previous year questions on Glycolysis, Gluconeogenesis and Their Regulation for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Biochemistry section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 30 live questions in Glycolysis, Gluconeogenesis and Their Regulation.
- 7 of 30 questions carry a verified exam year: 2017, 2018, 2019, 2020.
- Biochemistry is worth about 16 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 5 Sept 2026.
Q1.Glucose can be synthesized from all except
- AAmino acids
- BGlycerol
- CAcetoacetate✓ Correct answer
- DLactic acid
Q2.The glycolysis is regulated by
- AHexokinase
- BPhosphofructokinase
- CPyruvate kinase
- DAll of these✓ Correct answer
Q3.Activity of all of the following enzymes is increased in diabetes state except
- APyruvate carboxylase
- BPEP Carboxykinase
- CPyruvate dehydrogenase✓ Correct answer
- DGlucose 6 phosphatase
Q4.Importance of pyruvate to lactate formation in anaerobic glycolysis is production of:
- AFAD
- BNADH to NAD✓ Correct answer
- CATP
- DNAD to NADH
Q5.Not a substrate for gluconeogenesis
- AGlycerol
- BLeucine✓ Correct answer
- CLactate
- DPropionate
Q6.Gluconeogenesis is inhibited by?
- AGlucagon
- BInsulin✓ Correct answer
- CCholecystokinin
- D5 alpha hydroxylase synthases
Q7.Through what "permissive action" do glucocorticoids accelerate gluconeogenesis during fasting
- AGlucocorticoids stimulate the secretion of insulin, which activates gluconeogenic enzymes in the liver
- BGlucocorticoids inhibit the use of glucose by skeletal muscle
- CGlucocorticoids maintain the vascular response to norepinephrine
- DGlucocorticoids maintain the intracellular concentrations of many of the enzymes needed to carry out gluconeogenesis through effects on transcription✓ Correct answer
Q8.Enzyme activated by decrease in insulin glucagon ratio
- AGlucokinase
- BHexokinase
- CPFK
- Dglucose 6 phosphatase✓ Correct answer
Q9.Decreased glucose concentration in hepatic cells triggers all of the following except –
- AIncreased glucagon levels in blood
- BActivation of fructose-2,6-biphosphatase
- CInhibition of phosphofructokinase-2
- DIncreased fructose-2,6-biphosphate levels✓ Correct answer
Q10.All enzyme activity is increased in fasting state Except
- AAcetyl - CoA carboxylase✓ Correct answer
- BCarnitine acyl transferase
- CPEPCK
- DPyruvate carboxylase
Answer key
Q1: C. Acetoacetate; Q2: D. All of these; Q3: C. Pyruvate dehydrogenase; Q4: B. NADH to NAD; Q5: B. Leucine; Q6: B. Insulin; Q7: D. Glucocorticoids maintain the intracellular concentrations of many of the enzymes needed to carry out gluconeogenesis through effects on transcription; Q8: D. glucose 6 phosphatase; Q9: D. Increased fructose-2,6-biphosphate levels; Q10: A. Acetyl - CoA carboxylase.
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