Motor Neuron Disease and ALS
- Previous year questions on Motor Neuron Disease and ALS for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Medicine section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 6 live questions in Motor Neuron Disease and ALS.
- Medicine is worth about 33 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.In amyotrophic lateral sclerosis true statement is-a) Present with seizuresb) Lesion in ant. horn cellsc) Corticospinal tractd) Hyporeflexia
- Aabc
- Bbcd✓ Correct answer
- Cac
- Dbd
Q2.All of the following are genetic motor neuron diseases affecting predominantly lower motor neurons except
- ASpinal muscular atrophy
- BSandhoff's disease
- CAdult tay sachs disease
- DAdrenoleukodystrophy✓ Correct answer
Q3.Most common cause of death in amyotropic lateral sclerosis is
- ACardiac failure
- BRespiratory failure✓ Correct answer
- CRenal failure
- DLiver failure
Q4.A 45-year-old man presents to the clinic for evaluation of weakness in his arms and legs. The symptoms started gradually, and are now more noticeable and interfering with his ability to work as an electrician. On physical examination, the cranial nerves are normal, but there is weakness of his left handgrip and right leg quadriceps with loss of muscle bulk. There are obvious fasciculations over the left forearm and right thigh. Tone is increased in the arms and legs and the reflexes are brisk. Which of the following is the most likely diagnosis?
- Aamyotrophic lateral sclerosis (ALS)✓ Correct answer
- Bmyotonic muscular dystrophy
- Camyotonia congenita
- Dtabes dorsalis
Q5.Which of the following tests is abnormal in patients with ALS (Amyotrophic Lateral Sclerosis)?
- AV.E.P
- BMRI whole spine
- CCT whole Spine
- DElectromyography✓ Correct answer
Q6.Amyotrophic lateral sclerosis is associated with?
- AATM gene
- BSOD1 gene✓ Correct answer
- CNF2 gene
- DHIF - 1 gene
Answer key
Q1: B. bcd; Q2: D. Adrenoleukodystrophy; Q3: B. Respiratory failure; Q4: A. amyotrophic lateral sclerosis (ALS); Q5: D. Electromyography; Q6: B. SOD1 gene.
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