Multiple Sclerosis and Demyelinating Disease
- Previous year questions on Multiple Sclerosis and Demyelinating Disease for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Medicine section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 18 live questions in Multiple Sclerosis and Demyelinating Disease.
- 2 of 18 questions carry a verified exam year: 2018, 2020.
- Medicine is worth about 33 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 5 Sept 2026.
Q1.Which of the following is the most common initial presenting feature of multiple sclerosis:
- AOptic Neuritis✓ Correct answer
- BCerebellar Ataxia
- CInternuclear ophthalmoplegia
- DDiplopia
Q2.In Multiple sclerosis, Where does the defect occur?
- AOligodendrocytes
- BMyelin sheath✓ Correct answer
- CNode of Ranvier
- DNeuroglial cells
Q3.Which of the following is false regarding Multiple Sclerosis (MS)?
- AMore common in women and age of onset is between 20-40 years of age
- BRisk factors include vitamin D deficiency and cigarette smoking
- CPathological hallmark is axonal degeneration✓ Correct answer
- DHLA DRB1 in MHC class II is associated with 10% of disease risk
Q4.A patient has had recurrent optic neuritis bilaterally with transverse myelitis. Visual acuity in right eye is 6/60 and left eye is 6/18. Patient showed a 50% response to steroids. Diagnosis is?
- ANeuromyelitis Optica✓ Correct answer
- BSubacute combined degeneration of spinal cord(SACD)
- CPost cerebral artery stroke
- DNeuro-syphilis
Q5.Which of the following clinical features of demyelinating myelopathy least likely suggests a progression to multiple sclerosis?
- AComplete cord transection
- BBilateral visual loss
- CAbsence of oligoclonal bands✓ Correct answer
- DPoor prognosis
Q6.What is false regarding McDonald criteria for diagnosis of MS?
- ADissemination in space
- BDissemination in time
- CNeurological disturbance consistent with MS
- DOligoclonal IgG bands in serum✓ Correct answer
Q7.A child presented with clinical features of demyelination. The chances of progression to MS is least with which of the following:
- AAbsent oligoclonal band✓ Correct answer
- BBilateral visual loss
- CPoor recovery
- DCord complete transaction
Q8.Useless hand of oppenheim was described for
- AMultiple sclerosis✓ Correct answer
- BMedian nerve palsy
- CUlnar nerve palsy
- DAll of the above
Q9.The treatment options for patients with RRMS (relapsing-remitting multiple sclerosis) are all except?
- AInterferon-beta 1a
- BInterferon alpha✓ Correct answer
- CGlatiramer acetate
- DInterferon-beta 1b
Q10.Most Common presentation of Multiple Sclerosis is
- AOptic neuritis
- BInternuclear ophthalmoplegia
- CTransverse myelitis
- DClinically isolated syndrome✓ Correct answer
Answer key
Q1: A. Optic Neuritis; Q2: B. Myelin sheath; Q3: C. Pathological hallmark is axonal degeneration; Q4: A. Neuromyelitis Optica; Q5: C. Absence of oligoclonal bands; Q6: D. Oligoclonal IgG bands in serum; Q7: A. Absent oligoclonal band; Q8: A. Multiple sclerosis; Q9: B. Interferon alpha; Q10: D. Clinically isolated syndrome.
Other topics in Medicine
- Bedside Clinical Examination
- Disorders of Acid-Base Balance
- Anterior Pituitary Disorders
- Pituitary Tumours and Sheehan Syndrome
- Posterior Pituitary: ADH, Oxytocin and Diabetes Insipidus
- Syndrome of Inappropriate ADH Secretion (SIADH)
- Thyroid Disorders: Clinical Presentation
- Thyroid Disorders: Treatment Approach
- Multiple Endocrine Neoplasia Syndromes
- Phaeochromocytoma
- Cushing Syndrome
- Adrenal Insufficiency and Aldosterone Excess
- Diabetes Mellitus: Classification, Presentation and Treatment
- Diabetes Mellitus: Complications and Their Care
- Endocrinology of Reproduction
- Parathyroid Disorders and Calcium Balance
- Obesity
- Hyperbilirubinaemias and Liver Function Testing
- Alcohol-Related and Non-Alcoholic Fatty Liver Disease
- Viral Hepatitis
- Autoimmune Hepatobiliary Disease
- Acute Liver Failure and Transplantation
- Haemochromatosis and Wilson Disease
- Cirrhosis and Its Complications
- Peptic Ulcer Disease and Allied Conditions
- Approach to Diarrhoea
- Irritable Bowel Syndrome
- Inflammatory Bowel Disease: Presentation and Diagnosis
- Inflammatory Bowel Disease: Complications and Therapy
- Syndromes of Malabsorption
- Miscellaneous Gastrointestinal Disorders
- Vasculitis of Large and Medium Vessels
- Small Vessel Vasculitides
- Variable Vessel Vasculitis
- Crystal-Induced Arthritis
- Sjogren Syndrome and Scleroderma
- Sarcoidosis
- Dermatomyositis and Related Inflammatory Myopathies
- Seronegative Spondyloarthropathies
- SLE and Antiphospholipid Syndrome (APS)
- Rheumatoid Arthritis
- Asthma and COPD
- Pneumonia
- Interstitial Lung Disease and Pneumoconioses
- Lung Abscess and Bronchiectasis
- Tests of Pulmonary Function
- ARDS and Respiratory Failure
- Lung Tumours
- Sleep Apnoea
- Urinalysis
- Chronic Kidney Disease
- Acute Kidney Injury
- Dialysis and Renal Replacement Therapy
- Inherited and Cystic Kidney Disease
- Disorders of the Renal Tubules
- Renal Vascular Disease
- Assessment of Cardiovascular Disease
- Fundamentals of the ECG
- Supraventricular Tachyarrhythmias
- Ventricular Arrhythmias and Conduction Blocks
- Diseases of the Cardiac Valves
- Infective Endocarditis and Rheumatic Fever
- Systemic Hypertension and Vascular Disease
- Ischemic Heart Disease: Clinical Presentation and Diagnosis
- Ischemic Heart Disease: Complications and Treatment
- Myocarditis and the Cardiomyopathies
- Heart Failure
- Disorders of the Pericardium
- Pulmonary Hypertension
- Aortic and Peripheral Arterial Disease
- Pulmonary Embolism and DVT
- Neurological Assessment, GCS and Brain Death
- Epilepsy and Seizure Disorders
- Ischemic Stroke
- Haemorrhagic Stroke and Brainstem Syndromes
- Disorders of Peripheral Nerves
- Guillain-Barre Syndrome and Immune-Mediated Neuropathies
- Spinal Cord Disorders
- Myasthenia Gravis and Neuromuscular Junction Disease
- Headache Syndromes
- Disorders of Movement
- Motor Neuron Disease and ALS
- Ataxias
- Disorders of the Cranial Nerves
- Neurological Infections
- Hypoproliferative Anaemia
- Macrocytic Anaemia
- Haemolytic Anaemia
- Myeloproliferative Neoplasms and Aplastic Anaemia
- Disorders of Platelets
- Acute Leukaemias
- Plasma Cell Dyscrasias
- Chronic Myeloid and Chronic Lymphoid Leukaemia
- Hodgkin and Non-Hodgkin Lymphoma
- Disorders of Coagulation
- Haemoglobinopathies
- Transfusion Medicine and Blood Banking
- HIV and AIDS: Epidemiology and Clinical Features
- HIV and AIDS: Treatment and Prophylaxis
- Pulmonary and Extrapulmonary Tuberculosis
- Malaria, Dengue and Other Tropical Fevers
- COVID-19: Epidemiology and Clinical Features
- COVID-19: Diagnostic Investigations
- COVID-19: Management