Plasma Cell Dyscrasias
- Previous year questions on Plasma Cell Dyscrasias for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Medicine section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 26 live questions in Plasma Cell Dyscrasias.
- 1 of 26 questions carries a verified exam year: 2019.
- Medicine is worth about 33 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 5 Sept 2026.
Q1.Which of the following is not a characteristic feature of multiple myeloma?
- AIncreased Ig levels in serum
- BPositive ANA✓ Correct answer
- CPlasmacytosis
- DM spike on electrophoresis
Q2.Raised serum alkaline phosphatase is seen in all except:
- APagets disease
- BMultiple myeloma✓ Correct answer
- COsteomalacia
- DHyperthyroidism
Q3.Elderly female present with pain and swelling in the thigh. Xray shows multiple lytic lesions in distal femur with no periosteal reaction. Aspirate from the swelling shows homogenous serosanguinous fluid with RBCs. Which investigation can confirm the diagnosis?
- AS. Calcium levels
- BS. PTH levels✓ Correct answer
- CMRI
- DCD1a IHC
Q4.A 55-year-old male presents with renal failure. He gives a history of mild bone pains for the last 7 years. X-ray pelvis shows osteolytic lesions. Serum electrophoresis reveals a M spike. Peripheral blood evaluation showed rouleaux formation of RBCs with 35% plasma cells. Bone marrow examination showed a increase in plasma cells with aberrant antigen expression. The most likely diagnosis is:
- AMultiple myeloma
- BMonoclonal gammopathy with unknown significance
- CSmouldering myeloma
- DPlasma cell leukemia✓ Correct answer
Q5.A 60-year-old male has bone pain, vertebral collapse, fracture pelvis, the probable diagnosis is:
- AMultiple myeloma
- BSecondaries✓ Correct answer
- CTB
- DHemangioma of bone
Q6.A patient with pain in back. Lab investigation shows elevated ESR. X-ray skull shows multiple punched out lytic lesions. Most imp. Investigation to be done is -
- ASerum acid phosphatase
- BCT head with contrast
- CWhole body scan
- DSerum electrophoresis✓ Correct answer
Q7.A patient presents with pain in back. Lab investigation shows elevated ESR. X-ray skull shows multiple punched out lytic lesions. Most impoant investigation to be done is:
- ASerum acid phosphatase
- BCT head with contrast
- CWhole body scan
- DSerum electrophoresis✓ Correct answer
Q8.All the following are seen in Multiple myeloma except -
- AVisual Disturbance
- BBleeding tendency
- CProteinuria
- DDystrophic calcification✓ Correct answer
Q9.All of the following are minor criteria for multiple myeloma except -
- APlasmacytosis 20%
- BMultiple lytic lesion
- CIgA < 100 mg/dl and IgG < 600 mg/dl
- DPlasmacytoma on tissue biopsy✓ Correct answer
Q10.Which of the following types of multiple myeloma is maximally and most commonly associated with increased risk of hyperviscosity syndrome?
- AIgM✓ Correct answer
- BIgG
- CIgD
- DIgA
Answer key
Q1: B. Positive ANA; Q2: B. Multiple myeloma; Q3: B. S. PTH levels; Q4: D. Plasma cell leukemia; Q5: B. Secondaries; Q6: D. Serum electrophoresis; Q7: D. Serum electrophoresis; Q8: D. Dystrophic calcification; Q9: D. Plasmacytoma on tissue biopsy; Q10: A. IgM.
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