Degenerative, Toxic and Metabolic CNS Disease
- Previous year questions on Degenerative, Toxic and Metabolic CNS Disease for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Pathology section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 15 live questions in Degenerative, Toxic and Metabolic CNS Disease.
- 2 of 15 questions carry a verified exam year: 2018, 2019.
- Pathology is worth about 25 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.Tau protein seen in -
- AAlzhiemer's disease✓ Correct answer
- BLewy body dementia
- CPicks disease
- DAmylodosis
Q2.Risk factors for Alzheimer's include:-
- AKlinefelter syndrome
- BNoonam syndrome
- CDown's syndrome✓ Correct answer
- DTurner syndrome
Q3.'Marchiafava-Bignami' syndrome is
- AAlso called hospital addiction
- BRelated to alcoholism✓ Correct answer
- CCongenital
- DRelated to opium withdrawal
Q4.Which of the pathognomic feature of Alzheimer's disease?
- ALewy body
- BPlaques and tangles✓ Correct answer
- CPick bodies
- DRed neuronal degeneration
Q5.Neurofibrillary tangles and argyrophilic plaque are characteristic feature of
- AAlzheimers d/s✓ Correct answer
- BCJD
- CHepatic encephalopathy
- DParkinsonism
Q6.Acute changes in brain due to wernicke's encephalopathy in chronic alcoholics is most frequently seen in:
- AMamillary bodies✓ Correct answer
- BAqueduct of the midbrain
- CAround the third ventricle
- DAround the fourth ventricle
Q7.Which of these cells is often malfunctioning in Alzheimer's disease?
- AMicroglia✓ Correct answer
- BRadial glia
- CDendrites
- DOligodendrocytes
Q8.All of the following statements about Creutzfeldt-Jakob disease are true, EXCEPT
- AIt is a neurodegenerative disease
- BIt is caused by infectious proteins
- CMyoclonus is rarely seen✓ Correct answer
- DBrain biopsy is specific for diagnosis
Q9.All are features of Alzheimer's disease except
- AAmyloid Angiopathy
- BLewy bodies✓ Correct answer
- CNeurofibrillary tangles
- DSenile plaques
Q10.Lesions in Alzheimer's disease are commonest at
- AAmygdala
- BNucleus of Meynert✓ Correct answer
- CPineal gland
- DPrefrontal sulcus
Answer key
Q1: A. Alzhiemer's disease; Q2: C. Down's syndrome; Q3: B. Related to alcoholism; Q4: B. Plaques and tangles; Q5: A. Alzheimers d/s; Q6: A. Mamillary bodies; Q7: A. Microglia; Q8: C. Myoclonus is rarely seen; Q9: B. Lewy bodies; Q10: B. Nucleus of Meynert.
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