Obstructive and Restrictive Lung Disease
- Previous year questions on Obstructive and Restrictive Lung Disease for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Pathology section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 30 live questions in Obstructive and Restrictive Lung Disease.
- 2 of 30 questions carry a verified exam year: 2017, 2019.
- Pathology is worth about 25 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.Which of the following is true about alpha 1 antitrypsin?
- AInhibits elastase✓ Correct answer
- BInhibits trypsinogen activation in pancreas
- CInhibits trypsin activating protease
- DInhibits chymotrypsin
Q2.a1-antitrypsin deficiency chromosome is located on chromosome.. ?
- A10
- B14✓ Correct answer
- C17
- D11
Q3.WHICH of the following cell is most commonly associated with chronic allergic asthma ?
- ATH17
- BTH1
- CTH 2✓ Correct answer
- DTH 4
Q4.True about panacinar emphysema:
- AApical region commonly involved
- BUsually presents in 6th decade
- CAlpha-1 antitrypsin deficiency✓ Correct answer
- DInvolves whole lung
Q5.Increased Reid Index is used to characterized:
- AChronic Bronchitis✓ Correct answer
- BBronchiectasis
- CBronchial Asthma
- DEmphysema
Q6.Liver cirrhosis is associated with which type of emphysema in Pizz phenotype mutation?
- ACentriacinar
- BPanacinar✓ Correct answer
- CParaseptal
- DMultifocal
Q7.A family suffering a hereditary form of severe emphysema, with some family members also showing hepatic disease. Liver biopsy in one of the family members demonstrates increased reactivity with antibodies directed against a-1-antitrypsin. Serum levels of the enzyme are low, leading to increased activity of a number of serine proteases. Increased activity of which of the following serine proteases has been most closely tied to the emphysema that develops in these patients?
- AChymotrypsin
- BElastase✓ Correct answer
- CPlasmin
- DThrombin
Q8.Alpha-1 antitrypsin deficiency causes
- Acentri acinar emphysema
- Bpanacinar emphysema✓ Correct answer
- Ccentrilobar emphysema
- Dirregular emphysema
Q9.Most common type of emphysema
- APanacinar emphysema
- BIrregular emphysema
- CCentriacinar emphysema✓ Correct answer
- DParaseptal emphysema
Q10.Which of the following morphological changes in the lungs would be found in this patient of asthma
- ADestruction and dilation of the bronchi and bronchioles
- BFree air in the interstitium
- CViscid mucus plugs in the small airways✓ Correct answer
- DPeribronchiolar fibrosis
Answer key
Q1: A. Inhibits elastase; Q2: B. 14; Q3: C. TH 2; Q4: C. Alpha-1 antitrypsin deficiency; Q5: A. Chronic Bronchitis; Q6: B. Panacinar; Q7: B. Elastase; Q8: B. panacinar emphysema; Q9: C. Centriacinar emphysema; Q10: C. Viscid mucus plugs in the small airways.
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