Normocytic and Macrocytic Anemias
- Previous year questions on Normocytic and Macrocytic Anemias for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Pathology section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 21 live questions in Normocytic and Macrocytic Anemias.
- 3 of 21 questions carry a verified exam year: 2019, 2020.
- Pathology is worth about 25 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.A middle-aged male presented with history of fatigue and tiredness. On investigating, he had a hemoglobin of 8g/dL and MCV of 110 fl with the peripheral smear showing macrocytes and hypersegmented neutrophils. Which of the following is the most likely cause of the findings in this patient?
- AAncylostoma duodenale infestation
- BChronic alcoholism✓ Correct answer
- CChronic renal failure
- DColon cancer
Q2.Which of the following is a feature of Vit B12 deficiency anemia?
- AHypersegmented neutrophils
- BMacro-ovalocytes
- CMegaloblastic anemia
- DAll of the above✓ Correct answer
Q3.The earliest hematologic manifestation of megaloblastic anemia is
- AIncrease in MCV
- BHypersegmented polymorphs✓ Correct answer
- CThrombocytopenia
- DLeukopenia
Q4.Which type of anaemia is seen in vitamin B12 deficiency?
- AMicrocytic anemia
- BNormocytic anemia
- CDimorphic anemia
- DMacrocytic anemia✓ Correct answer
Q5.A 26 years old female presented with pallor and hemoglobin of 9.5 g/dl, PCV 30% and RBC count of 2 million/mm3. What is the most likely diagnosis?
- AIron deficiency anemia
- BSideroblastic anemia
- CThalassemia
- DFolic acid deficiency✓ Correct answer
Q6.Not seen in classical triad of megaloblastic anemia
- AHowell-Jolly bodies
- BReticulocytosis✓ Correct answer
- CHypersegmented neutrophil
- DMacro-ovalocytes
Q7."Macropolycytes" in peripheral smear is a feature of which of the following red cell disorders?
- AHereditary spherocytosis
- BIron deficiency anemia
- CSickle cell anemia
- DMegaloblastic anemia✓ Correct answer
Q8.Hypersegmented neutrophils are seen in?
- AMicrocytic hypochromic anemia
- BSideroblastic anemia
- CMegaloblastic anemia✓ Correct answer
- DHemolytic anemia
Q9.Macropolycyte in peripheral smear is a feature
- AHereditary spherocytosis
- BIron deficiency anaemia
- CSickle cell anaemia
- DMegaloblastic anaemia✓ Correct answer
Q10.Megaloblastic anemia resistant to treatment is seen with
- AAnticonvulsant therapy
- BHepatic cirrhosis
- COrotic aciduria✓ Correct answer
- DAll of the above
Answer key
Q1: B. Chronic alcoholism; Q2: D. All of the above; Q3: B. Hypersegmented polymorphs; Q4: D. Macrocytic anemia; Q5: D. Folic acid deficiency; Q6: B. Reticulocytosis; Q7: D. Megaloblastic anemia; Q8: C. Megaloblastic anemia; Q9: D. Megaloblastic anaemia; Q10: C. Orotic aciduria.
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