Molecular Basis of Cancer and Tumour Immunity
- Previous year questions on Molecular Basis of Cancer and Tumour Immunity for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Pathology section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 44 live questions in Molecular Basis of Cancer and Tumour Immunity.
- 2 of 44 questions carry a verified exam year: 2017, 2018.
- Pathology is worth about 25 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.All are true regarding retinoblastoma except:
- AThey play major role in cell cycle regulation
- BRequire deletion of both the Rb genes
- CFamilial variant is autosomal dominant in inheritance
- DChromosome 13p 14✓ Correct answer
Q2.BRAF V600E mutations are seen in all of the following Except
- ALangherhan's cell histiocytosis
- BErdheim Chester disease
- COvarian carcinoma
- DGrade II astrocytoma✓ Correct answer
Q3.Which is not a tumor Suppressor gene-
- AWT-1
- BRB
- CP53
- DRAS 902✓ Correct answer
Q4.Function of guardian of genome p53 is which of the following?
- AIncrease in Cell proliferation
- BEvasion of Apoptosis
- CInducer of necrosis
- DReduce cell mutation rate✓ Correct answer
Q5.Most common abnormality of proto-oncogene in human tumours is
- Ap53 point mutations
- BPoint mutation in RAS family gene✓ Correct answer
- CPoint mutation in C-kit gene
- DOverexpression of RET proto-oncogene
Q6.If the Rb gene phosphorylation is defective, which of the following will happen?
- ACell cycle will stop at GI phase✓ Correct answer
- BCell cycle will stop at G2 phase
- CThe cell cycle will progress and the cell will divide
- DThere will be no effect on cell cycle as for Rb gene phosphorylation is not needed
Q7.Which of the following is not a tumor suppressor gene?
- ApRb
- Bp16
- CPTCH
- Dc-erbB1✓ Correct answer
Q8.Which of following is not a tumor suppressor gene?
- ApRb
- BFHIT
- CPTCH
- Dc-erbB1✓ Correct answer
Q9.Nobel prize for medicine/physiology in 2018 for the discovery of:
- AApoptotic pathway
- BCrispr-Cas9
- CNegative immune regulation✓ Correct answer
- DMolecular mechanisms controlling circadian rhythm
Q10.Gene which inhibits cell cycle is -
- Ap53✓ Correct answer
- BRB
- Cp16
- DNotch receptor
Answer key
Q1: D. Chromosome 13p 14; Q2: D. Grade II astrocytoma; Q3: D. RAS 902; Q4: D. Reduce cell mutation rate; Q5: B. Point mutation in RAS family gene; Q6: A. Cell cycle will stop at GI phase; Q7: D. c-erbB1; Q8: D. c-erbB1; Q9: C. Negative immune regulation; Q10: A. p53.
Other topics in Pathology
- Cell Genetics, Adaptation and Cell Injury
- Necrosis and Apoptosis
- Intracellular Accumulations, Pathological Calcification and Cell Ageing
- The Acute Inflammatory Response
- Chemical Mediators and Granulomatous Inflammation
- Wound Healing and Tissue Repair
- Hemodynamic and Hemostatic Disorders
- Patterns of Inheritance
- Lysosomal and Glycogen Storage Disorders
- Chromosomal and Other Genetic Disorders
- Features and Epidemiology of Neoplasia
- Carcinogenesis, Paraneoplastic Syndromes and Tumour Markers
- Cells and Organs of the Immune System
- Hypersensitivity Reactions and Autoimmune Disease
- Immunodeficiency Disorders
- Amyloidosis and Transplant Rejection
- Histopathology Techniques and Special Stains
- Microcytic Anemias
- Normocytic and Macrocytic Anemias
- Hemolysis Overview and Intravascular Hemolysis
- Extravascular Hemolytic Anemias
- G6PD Deficiency and Autoimmune Hemolysis
- Disorders of Platelets
- Disorders of the Coagulation Cascade
- Blood Components and Transfusion Reactions
- Acute Lymphoblastic Leukemia (ALL)
- Acute Myeloid Leukemia (AML)
- Hodgkin Lymphoma
- Non-Hodgkin Lymphoma: Overview
- Non-Hodgkin Lymphoma: Low Grade
- Non-Hodgkin Lymphoma: High Grade
- Multiple Myeloma and Other Plasma Cell Neoplasms
- Myelodysplastic and Myeloproliferative Neoplasms and Histiocytosis
- White Cell Disorders and Lymphadenitis
- Atherosclerosis and Hypertensive Vascular Disease
- Aneurysms and Arterial Dissection
- Vasculitis
- Vascular Tumours
- Heart Failure and Ischemic Heart Disease
- Cardiomyopathies, Pericardial Disease and Cardiac Tumours
- Valvular and Congenital Heart Disease
- Rheumatic Fever and Endocardial Disease
- Diseases of the Glomerulus
- Tubulointerstitial, Vascular and Cystic Renal Disease
- Renal Tumours
- Pathology of the Lower Urinary Tract
- Pathology of the Female Genital Tract
- Pathology of the Male Genital Tract
- Infectious and Alcohol-Related Liver Disease
- Metabolic and Autoimmune Liver Disease
- Tumours of the Liver and Biliary Tract
- Gallbladder and Pancreatic Disease
- Esophageal Pathology
- Gastric Pathology
- Small Bowel Pathology
- Large Bowel: Non-Neoplastic Disease
- Large Bowel: Neoplastic Disease
- Congenital Anomalies, ARDS and Lung Infections
- Obstructive and Restrictive Lung Disease
- Lung Tumours
- Pituitary, Parathyroid and Endocrine Pancreas
- Thyroid Gland Pathology
- Adrenal Gland Pathology
- Breast Pathology
- Bone: Developmental Disorders, Infections and Tumours
- Joint and Soft Tissue Pathology
- Dermatopathology
- CNS Infections and Cerebrovascular Disease
- Degenerative, Toxic and Metabolic CNS Disease
- Tumours of the CNS
- Peripheral Nerve and Neuromuscular Pathology