Extravascular Hemolytic Anemias
- Previous year questions on Extravascular Hemolytic Anemias for NEET PG (National Eligibility cum Entrance Test - Postgraduate), from the Pathology section of the exam.
- Most questions here come from previous-year papers of Indian postgraduate medical entrance and licensing exams; where a paper and year are recorded the question carries them. The image-based questions are original vignettes written around an openly licensed figure, and were never asked in any exam.
- 16 live questions in Extravascular Hemolytic Anemias.
- Pathology is worth about 25 of 300 questions on the exam. See every subject’s weightage.
- Question set last updated 6 Sept 2026.
Q1.The following protein defects can cause hereditary spherocytosis, EXCEPT:
- AAnkyrin
- BPalladin
- CGlycophorin C✓ Correct answer
- DAnion transport protein
Q2.A 10yr old boy complains of fatigue and abdominal pain after playing football He also complains of painful swelling of digits in the past USG abdomen shows a small spleen which of the following is most likely diagnosis
- AIron deficiency anemia
- Bsickle cell anemia✓ Correct answer
- Cpancreatitis
- DMegaloblastic anemia
Q3.A 20 year old female presenting with anemia, mild jaundice for 2 years, peripheral smear showing spherocytes, the best investigation to be done is:
- AReticulocyte count
- BOsmotic fragility test
- CCoomb's test✓ Correct answer
- DBone marrow aspiration
Q4.Decreased osmotic fragility is seen in -
- AHereditary spherocytosis
- BSickle cell ds
- CAutoimmune hemolytic anemia
- DThalassemia✓ Correct answer
Q5.Auto haemolysis test is positive in -
- ABeta thalessemia
- BHereditary spherocytosis✓ Correct answer
- CVit E deficiency
- DSickle cell disease
Q6.A 23 years old female presented with jaundice and pallor for 2 months. Her peripheral blood smear shows the presence of spherocytes. The most relevant investigation to arrive at a diagnosis is -
- ARetics count
- BOsmotic fragility test
- CCoombs test✓ Correct answer
- DTests for PNH
Q7.Defect in hereditory spherocytosis lies in -
- AMembrane cytoskeleton✓ Correct answer
- BHemoglobin
- CEnzyme
Q8.Severe hereditary spherocytosis is seen due to the defect of the following protein
- ASpectrin✓ Correct answer
- BAnkyrin
- CBand 3
- DBand 4.2
Q9.Most common cause of hereditary spherocytosis?
- AActin
- BGlycophorin
- CSpectrin-Ankyrin complex✓ Correct answer
- DBand 4
Q10.In sickle cell anemia, the defect is in which chain -
- Aα-chain
- Bβ-chain✓ Correct answer
- CBoth the chains
- DNone of these
Answer key
Q1: C. Glycophorin C; Q2: B. sickle cell anemia; Q3: C. Coomb's test; Q4: D. Thalassemia; Q5: B. Hereditary spherocytosis; Q6: C. Coombs test; Q7: A. Membrane cytoskeleton; Q8: A. Spectrin; Q9: C. Spectrin-Ankyrin complex; Q10: B. β-chain.
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